Dissertation/Thesis Abstract

Pathopoiesis Mechanism of Smoking and Shared Genes in Pancreatic Cancer
by Labilles, Ulysses, Ph.D., Walden University, 2017, 169; 10624503
Abstract (Summary)

Pancreatic cancer (PC) remains a significant, unresolved issue because of its complex genetic blueprint and lack of reliable detection markers. The purpose of this study was to examine the possible correlation between tobacco use, gender, and age in the etiopathogenesis of PC and other cancer types with a shared-gene association (CTSG-A). The unified paradigm of cancer causation was used to understand the pathopoiesis mechanism of smoking and shared genes in PC. A cross-sectional study was performed using secondary data from the cancer survivorship module of the 2014 Behavioral Risk Factor Surveillance System survey. Results of ordinal logistic regression analyses indicated no correlation between smoking and prevalence of PC and CTSG-A, but gender and age were significant predictors. Gender has a statistically significant effect on the prediction of PC/ CTSG-A induction and promotion. Increased probability of developing the disease was found as the person reach the age between 62 and 69 years of age. Findings may enhance the understanding of environmental, genetic, and biodemographic interactions in disease evolution (induction, promotion, and expression periods). Findings may also be used to promote population health and improve health behaviors for individuals in vulnerable, high-risk groups.

Indexing (document details)
Advisor: Belin, Precilla
Commitee: Johnson, LaToya, Kuo, Wen-Hung, Riedel, Eric
School: Walden University
Department: Public Health
School Location: United States -- Minnesota
Source: DAI-B 79/02(E), Dissertation Abstracts International
Subjects: Health sciences, Public health, Epidemiology
Keywords: Biodemography, Cancer research, Epidemiology, Genomics, Pancreatic cancer, Public health
Publication Number: 10624503
ISBN: 9780355239430