Pancreatic cancer (PC) remains a significant, unresolved issue because of its complex genetic blueprint and lack of reliable detection markers. The purpose of this study was to examine the possible correlation between tobacco use, gender, and age in the etiopathogenesis of PC and other cancer types with a shared-gene association (CTSG-A). The unified paradigm of cancer causation was used to understand the pathopoiesis mechanism of smoking and shared genes in PC. A cross-sectional study was performed using secondary data from the cancer survivorship module of the 2014 Behavioral Risk Factor Surveillance System survey. Results of ordinal logistic regression analyses indicated no correlation between smoking and prevalence of PC and CTSG-A, but gender and age were significant predictors. Gender has a statistically significant effect on the prediction of PC/ CTSG-A induction and promotion. Increased probability of developing the disease was found as the person reach the age between 62 and 69 years of age. Findings may enhance the understanding of environmental, genetic, and biodemographic interactions in disease evolution (induction, promotion, and expression periods). Findings may also be used to promote population health and improve health behaviors for individuals in vulnerable, high-risk groups.
|Commitee:||Johnson, LaToya, Kuo, Wen-Hung, Riedel, Eric|
|School Location:||United States -- Minnesota|
|Source:||DAI-B 79/02(E), Dissertation Abstracts International|
|Subjects:||Health sciences, Public health, Epidemiology|
|Keywords:||Biodemography, Cancer research, Epidemiology, Genomics, Pancreatic cancer, Public health|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be