Dissertation/Thesis Abstract

Role of Genes in the Jak-Stat Pathway in the Innate Immune System and Immunosenescence in Drosophila melanogaster
by Lo, Amanda Susana, M.S., University of Maryland, Baltimore County, 2017, 56; 10275514
Abstract (Summary)

For many organisms, the immune system tends to deteriorate with age, leading to higher susceptibility to foreign pathogens. While several biological pathways are associated with immunity, the components of the Janus-kinase-Signal Transducers and Activators of Transcription (JAK-STAT) pathway on immunity at different age groups is unclear. This study explored the knock down effects of the Drosophila JAK-STAT pathway components and a candidate gene, robo3, in blood cells. Assessments of immune function were conducted through bacterial clearance assays and phagocytosis assay at one-week and five-weeks of age. This study suggests that some JAK-STAT pathway components important in other cell types seem to have less of a role in blood cells and immunity.

Indexing (document details)
Advisor: Leips, Jeff, Starz-Gaiano, Michelle
Commitee: Leips, Jeff, Miller, Stephen, Starz-Gaiano, Michelle
School: University of Maryland, Baltimore County
Department: Biological Sciences
School Location: United States -- Maryland
Source: MAI 56/06M(E), Masters Abstracts International
Subjects: Biology, Immunology
Keywords: Apt, Drosophila, Hop, Innate immune response, JAK-STAT, Robo3
Publication Number: 10275514
ISBN: 978-0-355-13557-2
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