For many organisms, the immune system tends to deteriorate with age, leading to higher susceptibility to foreign pathogens. While several biological pathways are associated with immunity, the components of the Janus-kinase-Signal Transducers and Activators of Transcription (JAK-STAT) pathway on immunity at different age groups is unclear. This study explored the knock down effects of the Drosophila JAK-STAT pathway components and a candidate gene, robo3, in blood cells. Assessments of immune function were conducted through bacterial clearance assays and phagocytosis assay at one-week and five-weeks of age. This study suggests that some JAK-STAT pathway components important in other cell types seem to have less of a role in blood cells and immunity.
|Advisor:||Leips, Jeff, Starz-Gaiano, Michelle|
|Commitee:||Leips, Jeff, Miller, Stephen, Starz-Gaiano, Michelle|
|School:||University of Maryland, Baltimore County|
|School Location:||United States -- Maryland|
|Source:||MAI 56/06M(E), Masters Abstracts International|
|Keywords:||Apt, Drosophila, Hop, Innate immune response, JAK-STAT, Robo3|
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