Dissertation/Thesis Abstract

Synthesis of Potential Halopyridine Based Inactivators of Dimethylarginine Dimethylaminohydrolase
by Wright, Dallas, M.S., Southern Illinois University at Edwardsville, 2017, 43; 10276018
Abstract (Summary)

Nitric oxide (NO) is an important gaseous molecule in the human physiology. NO has multiple functions within the body to maintain homeostatic relations. In particular NO is used an immunological response element as well as a critical factor cardiac and vascular function. Poor regulation of NO levels can result in multiple disease states such as cardiovascular disease in shortage of NO and high concentrations of NO are known to cause cancer. This means that control of NO production is important which gives potential to the development of NO regulators.

It is known that asymmetric dimethylargine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). ADMA levels are controlled by dimethylargine dimethylaminohydrolase (DDAH) which metabolizes ADMA to citrulline and methylamine. The goal of our research is to develop inhibitors that are similar in structure to ADMA to down regulate the expression of NO from NOS. In addition the inhibitor in development should contain a click chemistry region to act as a probe for detection of DDAH binding.

Indexing (document details)
Advisor: Dixon, Robert
Commitee: Jones, Myron, Lu, Yun
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 56/05M(E), Masters Abstracts International
Subjects: Biochemistry, Organic chemistry
Keywords: Inactivators, Nitric oxide synthase
Publication Number: 10276018
ISBN: 9780355051520
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