Dissertation/Thesis Abstract

Design and Synthesis of Superresolution Imaging Agents
by Williams, Jarrod C., Ph.D., Kent State University, 2012, 256; 10631379
Abstract (Summary)

The field of superresolution imaging relies on techniques where the locations of sequential subsets of fluorophores are recorded and compiled in order to generate sub diffraction limited images. In order to ensure that only a few emitters are present within a diffraction limited volume, it is necessary to synthesize fluorophores whose emission can be controlled via photoactivation. We report the design and synthesis of a series of versatile azido DCDHF dyes, a class of photoactivatable fluorogens that are easily tailored to a wide variety of superresolution scenarios.

Indexing (document details)
Advisor: Twieg, Robert
Commitee: Bunge, Scott, Ellman, Brett, Kline, Douglas, Sampson, Paul, Twieg, Robert
School: Kent State University
Department: College of Arts and Sciences / Department of Chemistry
School Location: United States -- Ohio
Source: DAI-B 78/11(E), Dissertation Abstracts International
Subjects: Chemistry, Organic chemistry
Keywords: Photochromic, Single molecule imaging
Publication Number: 10631379
ISBN: 978-0-355-01629-1
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