Dissertation/Thesis Abstract

Design and Synthesis of Organic Small Molecules for Industrial and Biomedical Technology Nanomaterial Augmentation
by Chapman, James Vincent, III, M.S., University of Colorado at Denver, 2017, 42; 10272651
Abstract (Summary)

Organic chemistry used to augment nanoparticles and nanotubes, as well as more traditional materials, is a subject of great interest across multiple fields of applied chemistry. Herein we present an example of both nanoparticle and nanotube augmentation with organic small molecules to achieve an enhanced or otherwise infeasible application. The first chapter discusses the modification of two different types of Microbial Fuel Cell (MFC) anode brush bristle fibers with positive surface charge increasing moieties to increase quantitative bacterial adhesion to these bristle fibers, and therefore overall MFC electrogenicity. Type-1 brush bristles, comprised of polyacrylonitrile, were modified via the electrostatic attachment of 1-pyrenemethylamine hydrochloride. Type-2 brush bristles, comprised of nylon, were modified via the covalent attachment of ethylenediamine. Both modified brush types were immersed in an E. Coli broth for 1 hour, stained with SYTO® 9 Green Fluorescent Nucleic Acid Stain from ThermoFisher Scientific (SYTO-9), and examined under a Biotek Citation 3 fluorescent microscope to visually assess differences in bacterial adherence. In both trials, a clear increase in amount of bacterial adhesion to the modified bristles was observed over that of the control. The second chapter demonstrates a potential biomedical technology application wherein a polymerizable carbocyanine-type dye was synthesized and bound to a chitosan backbone to produce a water-soluble photothermal nanoparticle. Laser stimulation of both free and NP-conjugated aqueous solutions of the carbocyanine dye with Near-Infrared (NIR) Spectrum Radiation showed an increase in temperature directly correlated with the concentration of the dye which was more pronounced in the free particle solutions.

Indexing (document details)
Advisor: Lee, Jung-Jae
Commitee: Reed, Scott, Wang, Xiaotai
School: University of Colorado at Denver
Department: Chemistry
School Location: United States -- Colorado
Source: MAI 56/04M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Organic chemistry, Biomedical engineering, Nanotechnology
Keywords: Anticancer, Electrogenic, Modification, Nanotechnology, Photothermal, Synthesis
Publication Number: 10272651
ISBN: 9781369774115
Copyright © 2019 ProQuest LLC. All rights reserved. Terms and Conditions Privacy Policy Cookie Policy
ProQuest