BACKGROUND: Nearly all patients with hepatitis C virus (HCV) infection can be treated successfully and achieve a virolgical cure; however, cure does not ensure the return of normal liver function. Non-invasive markers are needed to identify patients at high risk for continued liver dysfunction despite HCV cure.
OBJECTIVES: To evaluate liver volume, spleen volume, and model for end-stage liver disease (MELD) score prior to treatment as predictors of continued liver dysfunction post-cure.
METHODS: Multivariable logistic regression was used to identify factors associated with post-cure liver dysfunction, defined as serum albumin below the lower limit of normal. Liver and spleen volumes were calculated from computed tomography (CT) and magnetic resonance images (MRI).
RESULTS: One-predictor logistic regression models revealed that greater pre-treatment liver volume per ideal body weight [odds ratio (OR): 1.2 per mL/kg, p=0.008], lower pre-treatment spleen volume per ideal body weight (OR: 0.89 for every mL/kg, p=0.032), and lower pre-treatment MELD score (OR: 0.56 for every 1 unit increase in MELD score, p=0.002) were significantly related to recovery (albumin normalization).
SIGNIFICANCE: Liver volume, spleen volume, and the MELD score may all help to identify high-risk patients.
|Advisor:||Branch, Andrea D.|
|Commitee:||Gabrilove, Janice L., Moskowitz, Alan J., Woodward, Mark, Wyatt, Christina M., Zier, Karen|
|School:||Icahn School of Medicine at Mount Sinai|
|School Location:||United States -- New York|
|Source:||MAI 56/04M(E), Masters Abstracts International|
|Subjects:||Medicine, Medical imaging|
|Keywords:||Cirrhosis, Hepatitis c virus, Liver volume, Sustained virological response|
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