The breadth of considerations that affect antibiotic use in swine rearing is covered in this thesis. Chapter 1 introduces the theme and its relevance to readers from veterinary, producer, industry and regulatory fields. Chapter 2 reviews diseases and disorders of swine where antibiotics have been used effectively. Minimizing the potential for development of bacterial resistance must be considered when using antibiotics in pork production.
The application of antibiotic stewardship to pork production is conducted with experimental and epidemiologic study designs. Chapter 3 presents an experiment to evaluate the feeding of a non-antibiotic plant-derived alkaloid to nursery age swine challenged with antimicrobial resistant Salmonella enterica serovar Typhimurium DT104. The plant alkaloid improved growth, intestinal health, and pathogen elimination among nursery pigs similar to a conventional antibiotic growth promoter. Chapter 4 shows the effect of antibiotic selection on a nursery group performance. Nurseries .4 weeks postweaning, with moderate and severe disease, that received antibiotics for disease control, or displayed non-respiratory signs all had an increased odds for receiving an injectable antibiotic. Livability of groups that received chlortetracycline in the drinking water was 1.5% better than that of groups that received chlortetracycline with neomycin through the drinking water. Chapter 5 presents a position on residue limits and withdrawal times for the most commonly used antibiotics in swine health management. Over half of countries had an antibiotic residue limit set lower than Codex. High income countries had an increased odds of setting residue limits below Codex. A lower MRL increased the likelihood of a longer withdrawal time for only one of twelve antibiotics commonly used in swine.
Chapter 6 summarizes the implications of study findings for the veterinary, producer, industry and regulatory fields. Effective antibiotic stewardship being the result of evidence based medicine is supported by the study findings.
|Advisor:||Correa, Maria, Almond, Glen|
|School:||North Carolina State University|
|School Location:||United States -- North Carolina|
|Source:||DAI-B 78/08(E), Dissertation Abstracts International|
|Subjects:||Animal sciences, Animal Diseases, Veterinary services|
|Keywords:||Antibiotic use, Bacterial resistance, Livestock, Swine|
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