Quantitative concentrations of pharmaceuticals and personal care products (PPCP’s) have been detected and reported on worldwide. Many studies report concentrations of pharmaceuticals in the range as high as µg /L for surface, sewage treatment waters (influent and effluent,) and drinking water. Modern analytical techniques allow for detection and quantitation for concentrations below ng/L. Considering methods allow for the detection of analytes at such low concentrations, few studies have reported on pharmaceuticals in groundwater. To the best of the author’s knowledge no such studies have been performed to analyze rural waters. The focus of this study is to analyze rural Illinois groundwater for 21 PPCP’s and metabolites. Water samples, obtained from a wastewater treatment facility and wells in rural, southern Illinois, were analyzed for the PPCP’s by LC/MS/MS. The compounds of interest were extracted from 1L well water samples by solid phase extraction. Of the 21 compounds, 12 were detected within limits of quantitation in the groundwater samples. Results from the analysis of groundwater samples showed the highest concentrations for caffeine, primidone, naproxen and methyl paraben. The most ubiquitous compounds in groundwater were DEET and ketoprofen.