Hospitalized adults are at high risk of falling during their acute episode of care making fall prevention programs a critical element of care. Patient self-efficacy and engagement in fall-prevention activities are important aspects of fall-prevention programs. Education may play an important role in increasing self-efficacy and the likelihood of engagement; however, a gap in evidence explores the effect of patient education on self-efficacy and engagement among hospitalized older adults in preventing falls. This quasi-experimental study examined the effect of a multimedia program on hospitalized adults’ levels of fall risk awareness, self-efficacy, and engagement in fall prevention. Sixty hospitalized adults in an acute care setting in Broward County Florida participated in the study. Statistical findings suggested that multimedia program comprising a fall prevention video and nurse-led reinforcement program demonstrated increased level of fall risk awareness among hospitalized adults; however, there was a lack of significant findings on levels of falls self-efficacy and engagement after the intervention. Other findings showed (a) hospitalized adults with high level of falls self-efficacy were more engaged in falls prevention efforts, (b) there was a negative correlation between the number of medications and levels of falls self-efficacy and engagement, and (c) a multimedia program showed higher levels of falls self-efficacy and engagement for older adults without mobility aids after the intervention. Future research studies using multisite, mixed method approach could help identify potential barriers and facilitators to a culturally tailored, nurse-led multimedia fall-prevention study among older adults.