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Dissertation/Thesis Abstract

Investigating the antigen removal process of porcine cartilage in preparation of creating an osteochondral xenograft
by Kindred, Bradley Jeffery, M.S., Mississippi State University, 2016, 56; 10243154
Abstract (Summary)

With Athletes and individuals developing osteoarthritis and chondral defects at younger ages, long term treatments are in high demand. Total knee replacements only last for 10-15 years, so younger individuals would need to have multiple knee replacements within their lifetime. Allograft transplantation has shown to last long term and have high success rates, but the lack of donors and the possibility of damaging other areas of the knee to obtain tissue grafts has become a large concern.  Xenografts derived from porcine cartilage is cost effective and the supply is abundant. Two antigen removal processes were examined: a short term antigen removal process to maintain the mechanical stability of the tissue, and a long antigen removal process to minimize the risk of triggering an immune response. The antigen removal processes were compared, and the future precautions were determined to enhance the probability of creating a viable osteochondral xenograft preparation technique.

Indexing (document details)
Advisor: Elder, Steven
Commitee: Butler, James R., Liao, Jun, Simpson, Chartrisa L.
School: Mississippi State University
Department: Agricultural and Biological Engineering
School Location: United States -- Mississippi
Source: MAI 56/02M(E), Masters Abstracts International
Subjects: Molecular biology, Biomedical engineering, Biomechanics
Keywords: Antigen removal, Cartilage, Decellularization, Orthopedics, Tissue regeneration, Xenograft
Publication Number: 10243154
ISBN: 978-1-369-37692-0
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