With Athletes and individuals developing osteoarthritis and chondral defects at younger ages, long term treatments are in high demand. Total knee replacements only last for 10-15 years, so younger individuals would need to have multiple knee replacements within their lifetime. Allograft transplantation has shown to last long term and have high success rates, but the lack of donors and the possibility of damaging other areas of the knee to obtain tissue grafts has become a large concern. Xenografts derived from porcine cartilage is cost effective and the supply is abundant. Two antigen removal processes were examined: a short term antigen removal process to maintain the mechanical stability of the tissue, and a long antigen removal process to minimize the risk of triggering an immune response. The antigen removal processes were compared, and the future precautions were determined to enhance the probability of creating a viable osteochondral xenograft preparation technique.
|Commitee:||Butler, James R., Liao, Jun, Simpson, Chartrisa L.|
|School:||Mississippi State University|
|Department:||Agricultural and Biological Engineering|
|School Location:||United States -- Mississippi|
|Source:||MAI 56/02M(E), Masters Abstracts International|
|Subjects:||Molecular biology, Biomedical engineering, Biomechanics|
|Keywords:||Antigen removal, Cartilage, Decellularization, Orthopedics, Tissue regeneration, Xenograft|
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