Dissertation/Thesis Abstract

The effect of glucose on glucagon-like peptide -1 secretion in Hispanic adults with type two diabetes mellitus, impaired glucose tolerance, or normal glucose tolerance
by Adams, Elizabeth A. B., M.S., California State University, Long Beach, 2016, 69; 10195756
Abstract (Summary)

Though Hispanics have an increased risk of developing type 2 diabetes (T2D), it is not known if GLP-1 secretion contributes to this risk. We therefore investigated the effect of glucose on plasma GLP-1, insulin and glucagon responses in Hispanic adults with T2D (T2D-H), impaired glucose tolerance (IGT-H), or normal glucose tolerance (NGT-H).

Hormone responses to ingestion of 75 g glucose were evaluated over a 240-min period in a convenience sample of 16 men and 30 women aged 21-66 yrs. Results showed no significant difference in GLP-1 increase between NGT-H and NGT-nH nor was there any significant difference between Hispanic patients with varying degrees of glucose homeostasis (T2D-H, IGT-H, NGT-H). Despite an adequate GLP-1 response to glucose, we found abnormal insulin and glucagon responses to glucose in Hispanics with T2D and abnormal glucose homeostasis, respectively.

Indexing (document details)
Advisor: Wang, Long
Commitee: Gray, Virginia, Ipp, Eli
School: California State University, Long Beach
Department: Family and Consumer Sciences
School Location: United States -- California
Source: MAI 56/02M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Nutrition
Keywords: Glucagon-like peptide, Hispanic adults, Impaired glucose tolerance, Normal glucose tolerance, Type 2 diabetes
Publication Number: 10195756
ISBN: 9781369320244
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