Though Hispanics have an increased risk of developing type 2 diabetes (T2D), it is not known if GLP-1 secretion contributes to this risk. We therefore investigated the effect of glucose on plasma GLP-1, insulin and glucagon responses in Hispanic adults with T2D (T2D-H), impaired glucose tolerance (IGT-H), or normal glucose tolerance (NGT-H).
Hormone responses to ingestion of 75 g glucose were evaluated over a 240-min period in a convenience sample of 16 men and 30 women aged 21-66 yrs. Results showed no significant difference in GLP-1 increase between NGT-H and NGT-nH nor was there any significant difference between Hispanic patients with varying degrees of glucose homeostasis (T2D-H, IGT-H, NGT-H). Despite an adequate GLP-1 response to glucose, we found abnormal insulin and glucagon responses to glucose in Hispanics with T2D and abnormal glucose homeostasis, respectively.
|Commitee:||Gray, Virginia, Ipp, Eli|
|School:||California State University, Long Beach|
|Department:||Family and Consumer Sciences|
|School Location:||United States -- California|
|Source:||MAI 56/02M(E), Masters Abstracts International|
|Keywords:||Glucagon-like peptide, Hispanic adults, Impaired glucose tolerance, Normal glucose tolerance, Type 2 diabetes|
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