Dissertation/Thesis Abstract

Precision ketogenic therapy for seizures: Metabolic basis for change in nutrients changing phenotype
by Allen, Hannah J., Ph.D., University of Florida, 2016, 218; 10298906
Abstract (Summary)

Eliminating seizures and the need for medication is necessary in order to have a brain that works. Like medications, food can be prescribed to treat people with difficult to control seizures. Precision Ketogenic Therapy (PKT) is prescribed food therapy so that most of the calories come from fat. The mechanism of PKT is not known, but it is clear that changing the food one eats is strong enough to change the properties of the brain and result in no seizures for some patients. Tools were created tools to better define the food patients eat on PKT and better define outcomes of patients on PKT, which is step needed towards providing precision medicine to each patient.

Patients with intractable epilepsy were initiated onto PKT at UF Health Hospital. Caregivers kept daily records of seizures, medications, and at least weekly records of diet intake. A seizure load and med load score were created to better define response to PKT by including, in addition to seizure and medication number, seizure severity, type, length, and other variables for seizure response and prescribed dose relative to minimum recommended dose for medication response. A foodomic database was created, using existing nutrient information that contains food chemicals for current brand name products.

Patients with intractable epilepsy were on PKT for an average of 4.76 ±4.42 years. At 1 year (n=43), 44% of patients had greater than 50% reduction in seizures and 33% of patients had greater than 50% reduction in medications. At 5 years (n=23), 13% of patients were both med free and seizure-free and 65% of patients had greater than 50% reduction in both medications and seizures. The foodomic database contains 5,142 foods consumed by patients with a median of 122 nutrients per food.

Patients with intractable epilepsy respond to food therapy with a reduction in seizures and the need for medications. A foodomic database can be used to determine relationships between food intake and patient’s response to food therapy. The tools created can be used for a precision medicine approach to treating patients with intractable epilepsy.

Indexing (document details)
Advisor: Borum, Peggy
Commitee:
School: University of Florida
School Location: United States -- Florida
Source: DAI-B 78/05(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Nutrition, Physiology
Keywords: Epilepsy, Food therapy, Ketogenic diet, Precision Ketogenic Therapy, Seizures
Publication Number: 10298906
ISBN: 9781369419290
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