Dissertation/Thesis Abstract

Studying the Diversification of Nitro-Substituted Epoxyisoindolines
by Raeisi, Mojdeh, M.S., Southern Illinois University at Edwardsville, 2016, 113; 10164174
Abstract (Summary)

The Ugi-Smiles Diels-Alder reaction provides access to highly functionalized epoxyisoindoline products through a simple one-pot process. By necessity, the products each possess a nitro substituent, which can inhibit potential biological activity of these compounds. Reduction of the nitro functional group to an amine may overcome this and provide a route to diversify epoxyisoindoline products as well as to obtain quinoxalinone derivatives. This work reports a chemoselective method to prepare amino epoxyisoindolines from N -aryl epoxyisoindolines. Preparation of protected amines and the synthesis of novel quinoxalinone compounds are described, providing access to compounds that have the potential to exhibit interesting biological activities and pharmaceutical applications

Indexing (document details)
Advisor: Luesse, Sarah B.
Commitee: Lu, Yun, Sumita, Mina
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 56/02M(E), Masters Abstracts International
Subjects: Organic chemistry
Publication Number: 10164174
ISBN: 978-1-369-18760-1
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