Dissertation/Thesis Abstract

Modelling and Simulation of Particle-particle Interaction in a Magnetophoretic Bio-Separation Chip
by Alam, Manjurul, M.S., Southern Illinois University at Edwardsville, 2016, 68; 10161501
Abstract (Summary)

A Lagrangian particle trajectory model is developed to predict the interaction between cell-bead complexes and to track the positions and angles of the particles in a magnetophoretic bio-separation chip. Magnetic flux gradients are simulated in OpenFOAM CFD software and imported to MATLAB to obtain the particle trajectories. A connector vector is introduced to calculate the interaction force between two cell-bead particle complexes as they flow through a microfluidic device. The interaction force calculations are performed for cases where the connector vector is parallel, perpendicular, and at an angle of 45 degrees with the applied magnetic field. The trajectories of the particles are simulated by solving a system of eight ordinary differential equations using the fourth order Runge-Kutta method. The model is then used to study the effects of geometric positions and angles of the connector vector between the particles as well as the bead size, cell size, number of beads per cell, and flow rate on the interaction force and trajectories of the particles.

Indexing (document details)
Advisor: Darabi, Jeff
Commitee: Kweon, Soondo, Yan, Terry X.
School: Southern Illinois University at Edwardsville
Department: Mechanical and Industrial Engineering
School Location: United States -- Illinois
Source: MAI 56/01M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Biomedical engineering, Mechanical engineering
Keywords:
Publication Number: 10161501
ISBN: 9781369163810
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