Dissertation/Thesis Abstract

Association between chronic organochlorine exposure and immunotoxicity in the round stingray (Urobatis halleri)
by Sawyna, Jillian, M.S., California State University, Long Beach, 2016, 60; 10133989
Abstract (Summary)

Chronic organochlorine (OC) exposure has been shown to cause immune impairment in numerous vertebrate species. To determine if elasmobranchs exhibited compromised immunity due to high OC contamination along the coastal mainland of southern California, innate immune function was compared in round stingrays (Urobatis halleri) collected from the mainland and Santa Catalina Island. Proliferation and phagocytosis of peripheral blood, splenic, and epigonal leukocytes were assessed. Percent phagocytosis, and mean fluorescence index (MFI) were evaluated by quantifying % leukocytes positive for, and relative amounts of ingested fluorescent E. coli BioParticles. Total cell proliferation differed between sites, with mainland rays having a higher cell concentration in whole blood. PCB load explained significantly higher % phagocytosis in blood of mainland rays, while PCB and pesticide loads described increased splenic % phagocytosis and MFI in the mainland population. Data suggests strong OC-correlated immunostimulation; however, other site-specific environmental variables may be contributing to the observed effects.

Indexing (document details)
Advisor: Lowe, Christopher G.
Commitee: Fraser, Deborah A., Holland, Erika B.
School: California State University, Long Beach
Department: Biological Sciences
School Location: United States -- California
Source: MAI 55/05M(E), Masters Abstracts International
Subjects: Toxicology, Surgery, Immunology
Keywords: Elasmobranch immunology, Leukocyte proliferation, Pesticides, Phagocytosis, Polychlorinated biphenyls
Publication Number: 10133989
ISBN: 978-1-339-92491-5
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