Dissertation/Thesis Abstract

Molecular dynamic simulation studies of the androgen receptor complexed with 5α-dihydrotestosterone and an allosteric ligand
by Villarreal, Everardo, II, M.S., The University of Texas Rio Grande Valley, 2016, 47; 10134056
Abstract (Summary)

Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can bind to the BF-3 site, therefore inducing a change in the receptor and release of the endogenous ligand (DHT) before there is recruitment of other coactivators. The study

Indexing (document details)
Advisor: Kotsikorou, Evangelia
Commitee: Dean, Frank B., Gutierrez, Jose J., Parsons, Jason G.
School: The University of Texas Rio Grande Valley
Department: Department of Chemistry
School Location: United States -- Texas
Source: MAI 55/05M(E), Masters Abstracts International
Subjects: Biochemistry
Publication Number: 10134056
ISBN: 978-1-339-92558-5
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