Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can bind to the BF-3 site, therefore inducing a change in the receptor and release of the endogenous ligand (DHT) before there is recruitment of other coactivators. The study
|Commitee:||Dean, Frank B., Gutierrez, Jose J., Parsons, Jason G.|
|School:||The University of Texas Rio Grande Valley|
|Department:||Department of Chemistry|
|School Location:||United States -- Texas|
|Source:||MAI 55/05M(E), Masters Abstracts International|
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