Dissertation/Thesis Abstract

The effects of caffeinated beverage consumption and physical activity on current disability status in multiple sclerosis
by Bart-Greenough, Jessica, M.S.N., Bastyr University, 2016, 46; 10126862
Abstract (Summary)

Objective: Multiple Sclerosis (MS) is a disease involving myelin sheath destruction, with evidence of autoimmune activity. Because there is no cure for MS, the goal of treatment is to slow disease progression and control symptoms. The goal of this study is to determine if caffeinated beverage consumption or increased physical activity is related to lower disability status in MS patients, as well as to determine if there is an additive effect from these two factors.

Methods: Using a period-prevalence, online-questionnaire, 63 participants with MS were assessed for caffeinated beverage consumption, physical activity habits, and current disability status over the previous six months. Physical disability status was assessed using an estimated Expanded Disability Status Scale (eEDSS). The Patient Reported Outcomes in MS (PRO-MS) scale was used to measure severity of symptoms. The Patient Reported Outcome Measurement Information System (PROMIS) measured quality of life.

Results: No significant differences in eEDSS or PROMIS score were observed if participants consumed caffeinated beverages or did not. Participants who consumed caffeinated beverages showed a significantly higher PRO-MS score (31.1 ±21.6) compared to those who did not (20.9 ±16.2) (p<0.05). Participants who reported fewer hours of physical activity on average each week showed significantly lower PROMIS Mental scores (12.0 ±3.3) than those who reported moderate (13.9 ±3.1) or higher numbers of hours (14.7 ±3.1) (p<0.05). No significant additive effect from caffeinated beverage consumption and participation in physical activity together were observed.

Conclusion: Consumption of caffeinated beverages was associated with increased symptom severities in this MS population, but not with physical disability or quality of life measurements. Participants who reported more hours of physical activity each week also reported increased mental quality of life scores.

Indexing (document details)
Advisor: Harris, Cristen
Commitee: Kloubec, June, Wenner, Cynthia A.
School: Bastyr University
Department: Nutrition
School Location: United States -- Washington
Source: MAI 55/05M(E), Masters Abstracts International
Subjects: Neurosciences, Nutrition
Keywords: Caffeine, Multiple sclerosis, Physical activity
Publication Number: 10126862
ISBN: 978-1-339-84900-3
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