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Dissertation/Thesis Abstract

Elucidation mechanisms of the early immune response to chlamydial genital infection
by Smith, Cemeka Agugbuem, Ph.D., University of Arkansas for Medical Sciences, 2016, 178; 10124785
Abstract (Summary)

Chlamydia trachomatis is common cause for reproductive disease and pathology. Tissue injury is a direct consequence of the acute inflammatory response prescribed to mitigate infection in the host. Utilization of the intracervical C. muridarum model demonstrated a diverse chemokine/cytokine profile is established within the first 24 hours of infection. However, the precise mechanism(s) underlying the production of these chemokines and cytokines remain to be determined. This study aimed to further characterize the early inflammatory response to chlamydial genital infection and identify mechanism(s) promoting chemokine/cytokine induction during the initial stage of the host-chlamydiae interaction. (Abstract shortened by ProQuest.)

Indexing (document details)
Advisor: Rank, Roger G.
Commitee: Ponnappan, Usha, Scurlock, Amy, Stumhofer, Jason, Yeruva, Venkat L.
School: University of Arkansas for Medical Sciences
Department: Interdisciplinary Biomedical Sciences
School Location: United States -- Arkansas
Source: DAI-B 77/11(E), Dissertation Abstracts International
Subjects: Molecular biology, Cellular biology, Immunology
Keywords: Chemokines, Chlamydia, Cytokines, PMNs, TLR2, miRNA
Publication Number: 10124785
ISBN: 978-1-339-82883-1
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