Older adults’ knowledge and perceptions about Ebola have not been previously explored in the literature. A survey, administered during the Ebola outbreak in 2014, was performed to capture East Harlem senior residents’ knowledge about Ebola and identify their major sources of information, their self-reported levels of trust in city officials, and whether or not they would follow officials’ directions. Results using frequency testing showed that senior respondents were not knowledgeable about disease transmission. The major trusted sources of information identified were television and newspapers. Overall, respondents trusted city officials and were very likely to follow city instructions. This study is important because it elucidates the need for better information to be more efficiently disseminated through media during a health emergency.