The magnetic tweezer is a single molecule instrument that can measure the extension of biomolecules by tracking tethered probe particles. Due to its experimental simplicity and ability to apply a constant external force to probe particles, the magnetic tweezer is ideally suited to measuring single molecule dynamics under applied tension. In this thesis, I push the resolution of magnetic tweezers to angstrom spatial resolution by using a high-speed camera which can achieve more than 10 kHz temporal resolution. (Abstract shortened by ProQuest.)
|Advisor:||Saleh, Omar A.|
|Commitee:||Israelachvili, Jacob N., Lipman, Everett A., Safinya, Cyrus R.|
|School:||University of California, Santa Barbara|
|School Location:||United States -- California|
|Source:||DAI-B 77/09(E), Dissertation Abstracts International|
|Subjects:||Engineering, Optics, Biophysics|
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