A change in a stimulus response relationship implies that there has been a change in the internal state of the relevant behavior-generating network. Frequently, network states are persistent, biasing responses for some time following stimulus exposure. This benefits subsequent behavioral performance when the same stimulus is re-encountered. Alternatively, it can also negatively impact initiation of a second (distinct) task, i.e. there can be a task-switch cost. Recently, work from a few invertebrate model systems has begun to determine how experience dependent network states are mediated on a cellular/molecular level. A fundamental question I have addressed is, does the establishment of one network-state remove a prior state, or can two network states overlap and interact? In this thesis I provide data that indicate that in the feeding circuit of Aplysia, network states that promote incompatible behaviors can indeed overlap. In addition, I describe a novel role for a cyclic nucleotide gated ion-current, as supporting an experience dependent network state through a persistent modulation of cell excitability.
|Advisor:||Weiss, Klaudiusz R., Cropper, Elizabeth C.|
|Commitee:||Baxter, Mark, Brezina, Vladimir, Proekt, Alex, Salton, Steve|
|School:||Icahn School of Medicine at Mount Sinai|
|School Location:||United States -- New York|
|Source:||DAI-B 77/09(E), Dissertation Abstracts International|
|Keywords:||Central pattern generators, Implicit memory, Network states, Neuromodulation|
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