Dissertation/Thesis Abstract

Synthesis of Potential in Vivo Activity-Based Probes for Dimethylarginine Dimethylaminohydrolase-1 Based On Halopyridine Substitutes
by Kamusinga, Brian K., M.S., Southern Illinois University at Edwardsville, 2015, 70; 10024129
Abstract (Summary)

Nitric Oxide is an important molecule in human physiology. It has numerous functions within the body including acting as a cytotoxic factor released by some of the body's immunological response. ADMA an inhibitor for NOS is regulated by DDAH-1, ultimately DDAH-1 regulates the production of NO. Certain tumor cells upregulate DDAH-1 to aid in their survival and proliferation. The goal of this research was to synthesize halo-pyridine derived activity probes that can be used to study in vivo the activity of DDAH-1 like enzymes.

Indexing (document details)
Advisor: Dixon, Robert P.
Commitee: Lu, Yun, O'Brien, Leah
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 55/04M(E), Masters Abstracts International
Subjects: Molecular biology, Neurosciences, Biochemistry, Immunology
Keywords: Dimethylarginine Dimethylaminohydrolase-1 inhibitor, Dimethylarginine Dimethylaminohydrolase-1 inhibitors, No inhibitors
Publication Number: 10024129
ISBN: 9781339516974
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