Nitric Oxide is an important molecule in human physiology. It has numerous functions within the body including acting as a cytotoxic factor released by some of the body's immunological response. ADMA an inhibitor for NOS is regulated by DDAH-1, ultimately DDAH-1 regulates the production of NO. Certain tumor cells upregulate DDAH-1 to aid in their survival and proliferation. The goal of this research was to synthesize halo-pyridine derived activity probes that can be used to study in vivo the activity of DDAH-1 like enzymes.
|Advisor:||Dixon, Robert P.|
|Commitee:||Lu, Yun, O'Brien, Leah|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 55/04M(E), Masters Abstracts International|
|Subjects:||Molecular biology, Neurosciences, Biochemistry, Immunology|
|Keywords:||Dimethylarginine Dimethylaminohydrolase-1 inhibitor, Dimethylarginine Dimethylaminohydrolase-1 inhibitors, No inhibitors|
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