Dissertation/Thesis Abstract

Design, Numerical Evaluation and Experimental Validation of a Variable Valve to Mimic Valvular Diseases, In Vitro
by Manthripragada, Krishna Chaitanya, M.S., University of Louisiana at Lafayette, 2015, 123; 10002417
Abstract (Summary)

This thesis presents the design and development of a variable valve, which is capable of mimicking different pathological states of different valvular diseases. Onset of valve disease, mainly stenosis, is common in post left ventricular assist device (LVAD) implantation. Hydraulically, this condition manifests itself as a change in the opening profile of the heart valve, smaller effective hydraulic diameters. Studying the onset of this disease, during mock circulatory loop analysis of an LVAD design, enables the cardiovascular condition changes to be more appropriately modeled. This would provide insight into the impact of the changes in operating demands for the device over the course of its use. The challenge of producing a valve that can control its opening profile to mimic both healthy and stenosis states is thus essential. This project demonstrates the design and development phases of the valve, simulation of the variable valve in a hydraulic setting using Simulink Simscape physical modeling, and the prototype in vitro testing. In this project, different pathological severity states of aortic stenosis are successfully achieved by the developed valve.

Indexing (document details)
Advisor: Taylor, Charles
Commitee: Emblom, William, Guillory, John
School: University of Louisiana at Lafayette
Department: Mechanical Engineering
School Location: United States -- Louisiana
Source: MAI 55/03M(E), Masters Abstracts International
Subjects: Design, Biomedical engineering
Keywords: Adjustable valve, Aortic valve, Lvad, Medical device design, Stenosis, Variable valve
Publication Number: 10002417
ISBN: 9781339419275
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