This thesis presents the design and development of a variable valve, which is capable of mimicking different pathological states of different valvular diseases. Onset of valve disease, mainly stenosis, is common in post left ventricular assist device (LVAD) implantation. Hydraulically, this condition manifests itself as a change in the opening profile of the heart valve, smaller effective hydraulic diameters. Studying the onset of this disease, during mock circulatory loop analysis of an LVAD design, enables the cardiovascular condition changes to be more appropriately modeled. This would provide insight into the impact of the changes in operating demands for the device over the course of its use. The challenge of producing a valve that can control its opening profile to mimic both healthy and stenosis states is thus essential. This project demonstrates the design and development phases of the valve, simulation of the variable valve in a hydraulic setting using Simulink Simscape physical modeling, and the prototype in vitro testing. In this project, different pathological severity states of aortic stenosis are successfully achieved by the developed valve.
|Commitee:||Emblom, William, Guillory, John|
|School:||University of Louisiana at Lafayette|
|School Location:||United States -- Louisiana|
|Source:||MAI 55/03M(E), Masters Abstracts International|
|Subjects:||Design, Biomedical engineering|
|Keywords:||Adjustable valve, Aortic valve, Lvad, Medical device design, Stenosis, Variable valve|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be