Dissertation/Thesis Abstract

Quantitative Assessment of Fgfr1 Expression in Neurons and Glia of the Developing Mouse Brain
by Choubey, Lisha, M.S., University of Louisiana at Lafayette, 2015, 90; 10002386
Abstract (Summary)

Fibroblast growth factors (FGFs) and their receptors play a pivotal role in the developing and adult central nervous system (CNS). The binding of a suitable heparin sulfate proteoglycan and FGF to the extracellular ligand-binding domain of the fibroblast growth factor receptor (FGFR) induces stable receptor dimerization and activation through autophosphorylation of tyrosine residues in the cytoplasmic domain of the receptor. A signal is transduced though activating pathways, such as Ras/MAP kinase signaling and phospholipase-C gamma (PLC?). These mechanisms influence proliferation of stem cells, migration of cells, differentiation of cells into neurons or glia, and survival of neurons. FGFR1 is required for the development of the ventral and dorsal telencephalon. Inactivation of Fgfr1 results in reduced hippocampal volume, disruption of corpus callosum, hippocampal commissure due to abnormal midline glia development, and postnatal loss of cortical interneurons expressing parvalbumin in the dorsal telencephalon. Neuronal imbalances between inhibitory and excitatory neurons have been observed in neuropsychiatric disorders. Here we review the role of FGFR1 in CNS development.

Indexing (document details)
Advisor: Smith, Karen
Commitee: Chlan, Caryl, Watson, Glen
School: University of Louisiana at Lafayette
Department: Biology
School Location: United States -- Louisiana
Source: MAI 55/03M(E), Masters Abstracts International
Subjects: Molecular biology, Neurosciences, Cellular biology
Keywords: Brain, Fgfr1, Glia, Neurons
Publication Number: 10002386
ISBN: 9781339418964
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