Fibroblast growth factors (FGFs) and their receptors play a pivotal role in the developing and adult central nervous system (CNS). The binding of a suitable heparin sulfate proteoglycan and FGF to the extracellular ligand-binding domain of the fibroblast growth factor receptor (FGFR) induces stable receptor dimerization and activation through autophosphorylation of tyrosine residues in the cytoplasmic domain of the receptor. A signal is transduced though activating pathways, such as Ras/MAP kinase signaling and phospholipase-C gamma (PLC?). These mechanisms influence proliferation of stem cells, migration of cells, differentiation of cells into neurons or glia, and survival of neurons. FGFR1 is required for the development of the ventral and dorsal telencephalon. Inactivation of Fgfr1 results in reduced hippocampal volume, disruption of corpus callosum, hippocampal commissure due to abnormal midline glia development, and postnatal loss of cortical interneurons expressing parvalbumin in the dorsal telencephalon. Neuronal imbalances between inhibitory and excitatory neurons have been observed in neuropsychiatric disorders. Here we review the role of FGFR1 in CNS development.
|Commitee:||Chlan, Caryl, Watson, Glen|
|School:||University of Louisiana at Lafayette|
|School Location:||United States -- Louisiana|
|Source:||MAI 55/03M(E), Masters Abstracts International|
|Subjects:||Molecular biology, Neurosciences, Cellular biology|
|Keywords:||Brain, Fgfr1, Glia, Neurons|
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