Dissertation/Thesis Abstract

The Role of STING in Cancer
by Mo, Liu, M.S., National University of Singapore (Singapore), 2015, 83; 10006051
Abstract (Summary)

Innate immunity is the first line of host defense against infection by microbial pathogens, including viruses, bacteria and parasites. Recognition of nucleic acids by innate immune sensors is an important means to detect and protect against of pathogens in infected cells. In this project, we show that the cytosolic DNA sensor STING may regulate the levels of cytosolic DNA in cancer cells. Activation of STING in infected cells leads to the production of type I interferons. In accordance, constitutive expression of type I interferons partially depended on STING in cancer cells. In summary, our data suggest that STING contributes to recognition of cytosolic DNA presence in cancer cells.

Indexing (document details)
Advisor:
Commitee:
School: National University of Singapore (Singapore)
Department: Microbiology
School Location: Republic of Singapore
Source: MAI 55/03M(E), Masters Abstracts International
Source Type: DISSERTATION
Subjects: Oncology
Keywords:
Publication Number: 10006051
ISBN: 9781339439136
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