Dissertation/Thesis Abstract

Effects of VEGF treatment on human fetal mesenchymal stem cell properties supporting tissue repair
by Yang Xiaohui, Joan, Ph.D., National University of Singapore (Singapore), 2015, 128; 10005986
Abstract (Summary)

 Mesenchymal stem cells (MSCs) have been shown to have an innate ability to migrate towards injured tissues. Clinical trials have shown evidence of improvements in patients following the use of MSCs for tissue regeneration. However, the engraftment of the cells in the host tissues has consistently been reported to be low. Although it has not been investigated before, the poor engraftment may have an impact on the efficacy of the regulation and modulation of tissue repair by the donor MSCs.

The objective of this thesis is to develop an approach to enhance the low engraftment rates of the transplanted MSCs with an aim towards supporting more efficient tissue repair in future clinical applications. (Abstract shortened by UMI.)

Indexing (document details)
School: National University of Singapore (Singapore)
Department: Integrative Sciences and Engineering
School Location: Republic of Singapore
Source: DAI-A 77/06(E), Dissertation Abstracts International
Subjects: Cellular biology
Publication Number: 10005986
ISBN: 978-1-339-43857-3
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