Archaeal ATP synthases are the oldest yet least studied of the ATP synthases. Nanoarchaeum equitans (Neq) is a hyperthermophilic archaeal parasite that lacks genes for several of the major subunits of the ATP synthase. Thus, the Neq ATP synthase is either a primitive or partially constructed or has lost these genes due to its parasitic dependency. In this thesis, we report the crystal structure and biophysical studies of the regulatory B subunit (NeqB), the hexameric core NeqAB (A3B3) and its complexes with ADP and AMP-PNP (analogue of ATP) in an effort to understand the catalytic capabilities of the archaeal Neq ATP synthase. (Abstract shortened by UMI.)
|School:||National University of Singapore (Singapore)|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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