Dissertation/Thesis Abstract

Structural basis for a unique ATP synthase core complex from Nanoarchaeum equitans
by Mohanty, Soumya, Ph.D., National University of Singapore (Singapore), 2015, 123; 10006083
Abstract (Summary)

Archaeal ATP synthases are the oldest yet least studied of the ATP synthases. Nanoarchaeum equitans (Neq) is a hyperthermophilic archaeal parasite that lacks genes for several of the major subunits of the ATP synthase. Thus, the Neq ATP synthase is either a primitive or partially constructed or has lost these genes due to its parasitic dependency. In this thesis, we report the crystal structure and biophysical studies of the regulatory B subunit (NeqB), the hexameric core NeqAB (A3B3) and its complexes with ADP and AMP-PNP (analogue of ATP) in an effort to understand the catalytic capabilities of the archaeal Neq ATP synthase. (Abstract shortened by UMI.)

Indexing (document details)
Advisor:
Commitee:
School: National University of Singapore (Singapore)
Department: Biomedical Sciences
School Location: Republic of Singapore
Source: DAI-B 77/06(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Biomedical engineering
Keywords:
Publication Number: 10006083
ISBN: 9781339439457
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