Dissertation/Thesis Abstract

Ω-neurotoxins: Novel antagonists of nicotinic acetylcholine receptors from snake venom
by H. P, Varuna, Ph.D., National University of Singapore (Singapore), 2015, 203; 10006093
Abstract (Summary)

Various subtypes of nicotinic acetylcholine receptors (nAChRs) mediate ionotropic actions of acetylcholine in the central and peripheral nervous system. Due to the lack of highly selective nicotinic ligands, the precise location, functional roles and various disorders associated with nAChRs remain unclear. Neurotoxins isolated from snake venom have a natural high affinity and selectivity to nAChRs, which act as competitive antagonists of nAChRs. These neurotoxins may therefore be invaluable tools in studying nAChR physiology

The structure-function relationships of the classical neurotoxins, named á- neurotoxins, which belong to three-finger toxin (3FTx) family of snake venom neurotoxins are competitive antagonists with nano-molar affinity and high selectivity towards nAChRs. In addition, the functional site of about 15 residues involved in their interaction with nAChRs has been identified.

This thesis reports the characterization of a new group of competitive antagonists of nAChRs, Ω-neurotoxins.

Indexing (document details)
School: National University of Singapore (Singapore)
Department: Biochemistry
School Location: Republic of Singapore
Source: DAI-B 77/06(E), Dissertation Abstracts International
Subjects: Biochemistry
Publication Number: 10006093
ISBN: 978-1-339-43955-6
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