Various subtypes of nicotinic acetylcholine receptors (nAChRs) mediate ionotropic actions of acetylcholine in the central and peripheral nervous system. Due to the lack of highly selective nicotinic ligands, the precise location, functional roles and various disorders associated with nAChRs remain unclear. Neurotoxins isolated from snake venom have a natural high affinity and selectivity to nAChRs, which act as competitive antagonists of nAChRs. These neurotoxins may therefore be invaluable tools in studying nAChR physiology
The structure-function relationships of the classical neurotoxins, named á- neurotoxins, which belong to three-finger toxin (3FTx) family of snake venom neurotoxins are competitive antagonists with nano-molar affinity and high selectivity towards nAChRs. In addition, the functional site of about 15 residues involved in their interaction with nAChRs has been identified.
This thesis reports the characterization of a new group of competitive antagonists of nAChRs, Ω-neurotoxins.
|School:||National University of Singapore (Singapore)|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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