The detection of trans-QTLs is challenging due to the multiple testing problem and their small effect size. In contrast, the utilization of expression co-variation of a group of genes increases statistical power in detecting trans-acting variations. However, unknown batch effects are also causes of expression co+variation for a large number of genes. Therefore, in this study we aimed to identify and distinguish co-varying genes caused by either trans.effects or batch effects. (Abstract shortened by UMI.)
|School:||National University of Singapore (Singapore)|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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