Dissertation/Thesis Abstract

The detection of trans-acting influences upon human gene expression
by Yu, Quan, Ph.D., National University of Singapore (Singapore), 2015, 199; 10006073
Abstract (Summary)

The detection of trans-QTLs is challenging due to the multiple testing problem and their small effect size. In contrast, the utilization of expression co-variation of a group of genes increases statistical power in detecting trans-acting variations. However, unknown batch effects are also causes of expression co+variation for a large number of genes. Therefore, in this study we aimed to identify and distinguish co-varying genes caused by either trans.effects or batch effects. (Abstract shortened by UMI.)

Indexing (document details)
Advisor:
Commitee:
School: National University of Singapore (Singapore)
Department: Biochemistry
School Location: Republic of Singapore
Source: DAI-B 77/06(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Biochemistry
Keywords:
Publication Number: 10006073
ISBN: 978-1-339-43935-8
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