High-resolution fluorescence microscopy has become an essential tool in both biological and biomedical sciences, to directly visualize biological processes at the cellular and subcellular levels through specific fluorescence labeling. Among the fluorescence microscopy techniques, mega-electron-volt (MeV) ion-induced fluorescence microscopy has unique advantages because MeV ions can penetrate through biological cells with little deflection in their trajectories. The state-of-the-art bioimaging facility in the Centre for Ion Beam Applications, National University of Singapore can achieve sub-30 nm spatial resolutions for structural imaging of biological cells, which is well below the diffraction limits imposed by optical microscopy. Our aim is to achieve similar spatial resolutions for Ion Beam Induced Fluorescence Imaging. (Abstract shortened by UMI.)
|School:||National University of Singapore (Singapore)|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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