Dissertation/Thesis Abstract

Development and biological applications of high-resolution ion beam induced fluorescence microscopy
by Zhaohong, Mi, Ph.D., National University of Singapore (Singapore), 2015, 239; 10006061
Abstract (Summary)

 High-resolution fluorescence microscopy has become an essential tool in both biological and biomedical sciences, to directly visualize biological processes at the cellular and subcellular levels through specific fluorescence labeling. Among the fluorescence microscopy techniques, mega-electron-volt (MeV) ion-induced fluorescence microscopy has unique advantages because MeV ions can penetrate through biological cells with little deflection in their trajectories. The state-of-the-art bioimaging facility in the Centre for Ion Beam Applications, National University of Singapore can achieve sub-30 nm spatial resolutions for structural imaging of biological cells, which is well below the diffraction limits imposed by optical microscopy. Our aim is to achieve similar spatial resolutions for Ion Beam Induced Fluorescence Imaging. (Abstract shortened by UMI.)

Indexing (document details)
School: National University of Singapore (Singapore)
Department: Physics
School Location: Republic of Singapore
Source: DAI-B 77/06(E), Dissertation Abstracts International
Subjects: Physics
Publication Number: 10006061
ISBN: 978-1-339-43923-5
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