Perturbation of the balance between self-renewal and differentiation of stem cell may result in developmental defects or cancer formation. In recent years, Drosophila larval brain neuroblasts (NBs) have emerged as a model for understanding stem cell self-renewal and tumor formation. In particular, newly-identified Drosophila type II neuroblasts that develop through the transit-amplifying phase of the intermediate neural progenitors (INPs) are susceptible to impaired homeostasis if the restricted proliferative ability of INPs is unrestrained. However, while it is known that there are several type II specific transcription factors that regulate INP formation and prevent de-differentiation, the precise nature of the molecular mechanism preventing de-differentiation is largely unknown.
In this thesis, I demonstrate that Drosophila Brm chromatin remodeling complex regulates type II neuroblast homeostasis. (Abstract shortened by UMI.)
|School:||National University of Singapore (Singapore)|
|Department:||Integrative Sciences and Engineering|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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