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Growth inhibitory dioxonaphthoimidazoliums related to YM155: Synthesis and mechanistic investigations
by Sherman, Ho Si Han, Ph.D., National University of Singapore (Singapore), 2015, 212; 10006013
Abstract (Summary)
YM155 is a dioxonaphthoimidazolium analog with potent growth inhibitory activities on a variety of cancer cell lines. Although initially reported as a suppressor of survivin, its specificity has been queried with concerns raised over its purported DNA damaging activity. The purpose of this thesis was to investigate the hypothesis that a detailed understanding of the mode of action of YM155 would promote the development of dioxonaphthoimidazolium analogs as a promising class of anti-cancer therapeutics. (Abstract shortened by UMI.)
| Advisor: | |
| Commitee: | |
| School: | National University of Singapore (Singapore) |
| Department: | Pharmacy |
| School Location: | Republic of Singapore |
| Source: | DAI-B 77/06(E), Dissertation Abstracts International |
| Source Type: | DISSERTATION |
| Subjects: | Pharmacy sciences |
| Keywords: | |
| Publication Number: | 10006013 |
| ISBN: | 9781339438795 |
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