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YM155 is a dioxonaphthoimidazolium analog with potent growth inhibitory activities on a variety of cancer cell lines. Although initially reported as a suppressor of survivin, its specificity has been queried with concerns raised over its purported DNA damaging activity. The purpose of this thesis was to investigate the hypothesis that a detailed understanding of the mode of action of YM155 would promote the development of dioxonaphthoimidazolium analogs as a promising class of anti-cancer therapeutics. (Abstract shortened by UMI.)
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School: | National University of Singapore (Singapore) |
Department: | Pharmacy |
School Location: | Republic of Singapore |
Source: | DAI-B 77/06(E), Dissertation Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Pharmacy sciences |
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Publication Number: | 10006013 |
ISBN: | 978-1-339-43879-5 |