YM155 is a dioxonaphthoimidazolium analog with potent growth inhibitory activities on a variety of cancer cell lines. Although initially reported as a suppressor of survivin, its specificity has been queried with concerns raised over its purported DNA damaging activity. The purpose of this thesis was to investigate the hypothesis that a detailed understanding of the mode of action of YM155 would promote the development of dioxonaphthoimidazolium analogs as a promising class of anti-cancer therapeutics. (Abstract shortened by UMI.)
|School:||National University of Singapore (Singapore)|
|School Location:||Republic of Singapore|
|Source:||DAI-B 77/06(E), Dissertation Abstracts International|
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