Dissertation/Thesis Abstract

Growth inhibitory dioxonaphthoimidazoliums related to YM155: Synthesis and mechanistic investigations
by Sherman, Ho Si Han, Ph.D., National University of Singapore (Singapore), 2015, 212; 10006013
Abstract (Summary)

YM155 is a dioxonaphthoimidazolium analog with potent growth inhibitory activities on a variety of cancer cell lines. Although initially reported as a suppressor of survivin, its specificity has been queried with concerns raised over its purported DNA damaging activity. The purpose of this thesis was to investigate the hypothesis that a detailed understanding of the mode of action of YM155 would promote the development of dioxonaphthoimidazolium analogs as a promising class of anti-cancer therapeutics. (Abstract shortened by UMI.)

Indexing (document details)
Advisor:
Commitee:
School: National University of Singapore (Singapore)
Department: Pharmacy
School Location: Republic of Singapore
Source: DAI-B 77/06(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Pharmacy sciences
Keywords:
Publication Number: 10006013
ISBN: 9781339438795
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