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Objective: To identify genomic variance of C. difficile strains to determine diversity and transmission potential which can guide future directions in clinical care and hospital policy. Study Design: We analyzed epidemiological and genomic data from 35 patients with laboratory confirmed C. difficile infection (CDI) in two three-month periods in 2011 and 2014 at a large urban hospital. Whole genome sequencing was conducted on all isolates; further analysis was conducted for 13 cases of CDI with the highly virulent NAP1 strain. Results: Overall strain diversity within the hospital was analyzed. Stable prevalence among the NAP1 strain indicated an endemic status; no other strain exhibited a specific pattern. Genomic analysis identified at least 4 distinct subgroups in the NAP1 strain specific to the hospital. Conclusion: Genomic analysis is necessary to unequivocally identify C. difficile transmission and can provide both clinical and procedural benefit.
Advisor: | van Bakel, Harm |
Commitee: | |
School: | Icahn School of Medicine at Mount Sinai |
Department: | Public Health |
School Location: | United States -- New York |
Source: | MAI 55/03M(E), Masters Abstracts International |
Source Type: | DISSERTATION |
Subjects: | Genetics, Public health |
Keywords: | |
Publication Number: | 1606872 |
ISBN: | 978-1-339-40493-6 |