Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.
|Advisor:||Ewert, Dan L.|
|Commitee:||Glower, Jake, Hackney, Kyle J., Schroeder, Mark J.|
|School:||North Dakota State University|
|Department:||Electrical and Computer Engineering|
|School Location:||United States -- North Dakota|
|Source:||MAI 55/03M(E), Masters Abstracts International|
|Subjects:||Biomedical engineering, Medicine, Physiology|
|Keywords:||Cardiac coupling, Cardiac modeling, Integrative physiology, Ventricular-arterial coupling|
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