Dissertation/Thesis Abstract

The capillary-centric model of cardiac coupling-as-thermodynamics
by Taylor, Andrew James David, M.S., North Dakota State University, 2015, 91; 1606114
Abstract (Summary)

Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.

Indexing (document details)
Advisor: Ewert, Dan L.
Commitee: Glower, Jake, Hackney, Kyle J., Schroeder, Mark J.
School: North Dakota State University
Department: Electrical and Computer Engineering
School Location: United States -- North Dakota
Source: MAI 55/03M(E), Masters Abstracts International
Subjects: Biomedical engineering, Medicine, Physiology
Keywords: Cardiac coupling, Cardiac modeling, Integrative physiology, Ventricular-arterial coupling
Publication Number: 1606114
ISBN: 978-1-339-36322-6
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