Glyphosate-resistant Palmer amaranth (Amaranthus palmeri [S.] Wats) is an economically troublesome weed to southeastern United States soybean (Glycine max [L.] Merr.) growers. Palmer amaranth is troublesome due to its evolution of resistance to multiple herbicide modes of action, competiveness, and prolific seed production. Greenhouse studies were conducted at the Delta Research and Extension Center in Stoneville, MS to evaluate different rates of 2,4-dichlorophenoxyacetic acid (2,4-D) for control of Palmer amaranth. Field experiments were conducted at the Delta Research and Extension Center in Stoneville, MS in 2013 and 2014 to evaluate Palmer amaranth emergence using a cultural practice and a residual herbicide. Field experiments were also conducted at the Delta Research and Extension Center in Stoneville, MS in 2013 and 2014 to evaluate Palmer amaranth control with applications of glyphosate, glufosinate, and 2,4-D alone and in mixtures.