This work presents several scalable methods for fabricating a micro preconcentrator chemical trap which can be applied to a microanalytical gas sensing system for the purpose of analyte amplification and prefiltering. The implementation of a microfabricated analytical gas sensing system capable of identifying inflammatory biomarkers in breath as a point-of-care diagnostic device would allow for rapid, low-cost, noninvasive monitoring of children with asthma. The micro preconcentrator device substrates were fabricated from low-cost, highly durable borosilicate glass. Devices were fabricated using both standard planar processing methods borrowed from the microelectronic canon, as well as directly machined using a modified low cost desktop milling machine. In addition, a novel method is presented for fabrication and packaging of a device made entirely of glass. The micro preconcentrators include a photolithographically defined micro resistive heating element for rapid thermal desorption without the need for secondary cryofocusing. The final device is shown to have minimal chemical background and sufficient fidelity to differentiate between the breath of two human subjects when coupled with a benchtop gas chromatograph and flame ionization detector.
|Advisor:||Horsley, David A.|
|Commitee:||Davis, Christina E., Kennedy, Ian M.|
|School:||University of California, Davis|
|Department:||Mechanical and Aeronautical Engineering|
|School Location:||United States -- California|
|Source:||MAI 55/02M(E), Masters Abstracts International|
|Keywords:||Breath sampling, Lab-on-chip, Low-cost, Microfabrication, Micromachining, Preconcentrator|
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