Dissertation/Thesis Abstract

Anti-tumor immune responses against MTLn3 mammary adenocarcinoma
by Carter, KiahRae, M.S., University of North Texas Health Science Center at Fort Worth, 2014, 45; 1602719
Abstract (Summary)

Lymphatic pump treatment (LPT) is used as a lymph enhancing therapy to treat edema. In animals, LPT enhanced lymphatic flow, released leukocytes and inflammatory mediators into lymph, and inhibited pulmonary tumor formation. Therefore, we hypothesized the administration of LPT would enhance immunity and inhibit primary breast tumor growth. Rats were subcutaneously injected with MTLn3 and divided into MTLn3, MTLn3+Sham-LPT and MTLn3+LPT group. Sham group received light touch under anesthesia and LPT group received treatment under anesthesia. There were no changes in tumor growth between groups. Administration of Sham-LPT resulted in an increase in tumor-adjacent lymph node weight. Collectively, our data suggests LPT did not enhance primary tumor growth and may also protect against the pathogenesis exhibited by sham-LPT.

Indexing (document details)
Advisor: Hodge, Lisa M.
Commitee: Jones, Harlan, Jung, Marianna, Simecka, Jerry
School: University of North Texas Health Science Center at Fort Worth
Department: Microbiology and Immunology
School Location: United States -- Texas
Source: MAI 55/02M(E), Masters Abstracts International
Subjects: Immunology
Keywords: Breast cancer, Immune response, Lymphatic pump treatment
Publication Number: 1602719
ISBN: 978-1-339-18561-3
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