Nitric Oxide is an important molecule in human cells. It is responsible for multiple functions in various systems including the cardiovascular, immune, nervous, digestive, and reproductive systems. Nitric oxide is synthesized by the enzyme nitric oxide synthase, and its activity is controlled by the levels of asymmetric dimethyl arginine (ADMA) which in turn are controlled by Dimethylaminohydrolase (DDAH). DDAH is an important enzyme for study due to its ability to indirectly control nitric oxide synthase. 2-chloroacetimidine is an inhibitor of DDAH. Synthesizing molecules that contain a 2-chloroacetimidine moiety and a retrievable chemical tail could prove to be instrumental in further studying DDAH and other enzymes with similar reactivity in their active sites.
|Commitee:||Luesse, Sarah, O'Brien, Leah|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 55/02M(E), Masters Abstracts International|
|Subjects:||Biogeochemistry, Organic chemistry|
|Keywords:||Asymmetric dimethyl arginine, Chloroacetimidine, Click chemistry, Dimethylaminohydrolase, Nitric oxide, Nitric oxide synthase|
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