Dissertation/Thesis Abstract

Synthesis of 4-[(2-chloroethanimidamido) methyl –N- (prop-2-yn-1-yl) benzamide, a possible in vivo activity probe of DDAH-like enzymes
by Ratz, Patrick, M.S., Southern Illinois University at Edwardsville, 2015, 50; 1602062
Abstract (Summary)

Nitric Oxide is an important molecule in human cells. It is responsible for multiple functions in various systems including the cardiovascular, immune, nervous, digestive, and reproductive systems. Nitric oxide is synthesized by the enzyme nitric oxide synthase, and its activity is controlled by the levels of asymmetric dimethyl arginine (ADMA) which in turn are controlled by Dimethylaminohydrolase (DDAH). DDAH is an important enzyme for study due to its ability to indirectly control nitric oxide synthase. 2-chloroacetimidine is an inhibitor of DDAH. Synthesizing molecules that contain a 2-chloroacetimidine moiety and a retrievable chemical tail could prove to be instrumental in further studying DDAH and other enzymes with similar reactivity in their active sites.

Indexing (document details)
Advisor: Dixon, Robert
Commitee: Luesse, Sarah, O'Brien, Leah
School: Southern Illinois University at Edwardsville
Department: Chemistry
School Location: United States -- Illinois
Source: MAI 55/02M(E), Masters Abstracts International
Subjects: Biogeochemistry, Organic chemistry
Keywords: Asymmetric dimethyl arginine, Chloroacetimidine, Click chemistry, Dimethylaminohydrolase, Nitric oxide, Nitric oxide synthase
Publication Number: 1602062
ISBN: 9781339154053
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