The purpose of this research was to examine the complexation of carboplatin and λ-DNA via atomic force microscopy. This project had the challenge of getting the necessary resolution which lead to the need to examine and improve upon the experimental protocol. These resolution issues were fixed by eliminating contamination, and by developing more consistent means of DNA application. The carboplatin and DNA complexation was then able to be observed. Initial indications are consistent with expectations because the DNA appears to become more condensed over time but further examination is required.
|Advisor:||Voss, Eric J.|
|Commitee:||Shabestary, Nahid, Shaw, Michael|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 55/02M(E), Masters Abstracts International|
|Subjects:||Biochemistry, Inorganic chemistry|
|Keywords:||Atomic force microscopy, Carboplatin|
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