Sialic acids are a series of 2-keto-3-deoxy-nanonic acid, which have more than 50 naturally occurring members, the most common of which is N-acetyl Neuraminic acid. In nature, sialic acid is found at the terminal position of glycoconjugate chains and is usually attached to another sialic acid or a galactose molecule as ? glycosidic linkages. Sialic acid has been connected to a variety of biological functions, notably in cell-cell communication, oncogenesis, and cell mobility. For this diversity in biological functions sialic acid makes a great therapeutic target, and therefore is important not only to understand mechanism of sialylations to discover new ways of controlling the stereoselectivity of sialylation reaction and improve yields. Previously we reported the use of 2-Thio sialyl donor derivatives with TBDMS group at C-4, which lead to great stereocontrol. Herein we describe the introduction of novel protecting groups at C-4 and their testing as sialyl donors. Our preliminary results show that monochloroacetyl group is activating and ? stereocontrolling.
|Advisor:||De Meo, Cristina|
|Commitee:||Luesse, Sarah, Shabestary, Nahid|
|School:||Southern Illinois University at Edwardsville|
|School Location:||United States -- Illinois|
|Source:||MAI 55/02M(E), Masters Abstracts International|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be