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Dissertation/Thesis Abstract

Characterization of an emerging tendon progenitor cell network during early embryonic tendon development
by von Flotow, Friedrich, M.S., Tufts University, 2015, 80; 1601708
Abstract (Summary)

Tendons are important tissues with unique mechanical properties necessary for their function. Tendon injuries require lengthy rehabilitation, with adult healing resulting in mechanically inferior scar tissue. A more complete understanding of the development of embryonic tendon may lead to advances in the field of tendon tissue engineering and regeneration. Mechanical properties of embryonic tendon are not dependent on the same factors as mature tendon, and during early development, embryonic tendon cells are maintained at a high density. They also contain actin filaments that increase in organization and span cells. These results suggest the importance of a tendon progenitor cell (TPC) network to emerging tendon functional properties. We examine the proliferation and apoptosis activities of resident TPCs as contributors to cell density maintenance. We characterize the TPC network by visualizing points of cell-cell contact via cell membrane staining as well as staining for the actin cytoskeleton. Finally, we characterize various cell-cell proteins as crosslinks in the TPC network and compare their expression and distribution. These data provide a deeper understanding of embryonic tendon development and the role of cellular contributions to the emerging functional characteristics of tendon.

Indexing (document details)
Advisor: Kuo, Catherine K.
Commitee: Kaplan, David L., Yelick, Pamela C.
School: Tufts University
Department: Biomedical Engineering
School Location: United States -- Massachusetts
Source: MAI 55/01M(E), Masters Abstracts International
Subjects: Molecular biology, Cellular biology, Biomedical engineering
Keywords: Cell network, Embryonic, Tendon development, Tissue engineering
Publication Number: 1601708
ISBN: 978-1-339-14001-8
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