The neurotransmitters gamma aminobutyric acid (GABA) and nitric oxide (NO) play a role in maintaining the larval state in the eastern mud snail, Nassarius obsoletus, but how GABAergic and nitrergic neurons are organized in the neural circuit that controls metamorphosis is unknown. Because of previous work by other members of my laboratory, I hypothesized that GABAergic neurons would be upstream from the nitrergic ones. Larval N. obsoletus were exposed to various combinations of GABAergic and nitrergic compounds in bath application and the resulting numbers of metamorphosed individuals were counted after 24 and 48 hours.. I performed multiple sets of experiments and while some indicated that GABAergic neurons were upstream from nitrergic ones the data as a whole did not reveal a clear organizational scheme to this pathway, so I suggest instead that GABA and NO may function in separate pathways to influence the onset of metamorphosis.
|Advisor:||Leise, Esther M.|
|Commitee:||Hens, Mark, Lepri, John|
|School:||The University of North Carolina at Greensboro|
|Department:||College of Arts & Sciences: Biology|
|School Location:||United States -- North Carolina|
|Source:||MAI 55/01M(E), Masters Abstracts International|
|Subjects:||Biology, Neurosciences, Zoology|
|Keywords:||Apical ganglion, GABA, Metamorphosis, Mollusc, Neurons, Nitric oxide|
Copyright in each Dissertation and Thesis is retained by the author. All Rights Reserved
The supplemental file or files you are about to download were provided to ProQuest by the author as part of a
dissertation or thesis. The supplemental files are provided "AS IS" without warranty. ProQuest is not responsible for the
content, format or impact on the supplemental file(s) on our system. in some cases, the file type may be unknown or
may be a .exe file. We recommend caution as you open such files.
Copyright of the original materials contained in the supplemental file is retained by the author and your access to the
supplemental files is subject to the ProQuest Terms and Conditions of use.
Depending on the size of the file(s) you are downloading, the system may take some time to download them. Please be