We have found that calixarenes are good receptors of choline (trimethylammonium group) and they have strong affinity to form host-guest complexes with a variety of molecules carrying this moiety. Furthermore, the ability of lower rim carboxylic acid calix[n]arenes and upper rim phosphonic acid functionalized calixarene to transport choline-conjugated drugs through a liquid membrane was discovered. The results demonstrate that these systems are highly efficient toward transporting choline-conjugated targets, as well as neurotransmitters that possess ionizable amine termini. The breadth of compounds that are transported is significant, facing limitations only when the payloads become extremely lipophilic. These developments reveal new approaches towards attempting synthetic receptor mediated selective small molecule transport in vesicular and cellular systems.
|Advisor:||Schramm, Michael P.|
|Commitee:||Buonora, Paul T., Marinez, Eric R.|
|School:||California State University, Long Beach|
|Department:||Chemistry and Biochemistry|
|School Location:||United States -- California|
|Source:||MAI 55/01M(E), Masters Abstracts International|
|Subjects:||Chemistry, Analytical chemistry, Organic chemistry|
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