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Dissertation/Thesis Abstract

Early exposure to ketamine does not affect nicotine reward during adolescence in male and female rats
by Bowman, Melodi A., M.A., California State University, Long Beach, 2015, 73; 1597736
Abstract (Summary)

Children are commonly prescribed fluoxetine to manage their depressive symptoms, although evidence suggests many fail to respond to this treatment. Recently, low doses of ketamine were shown to work as a fast-acting and long-lasting antidepressant, however, it is unclear what the long-term effects are of using ketamine in pediatric populations. Thus, this thesis examined whether early-life exposure to ketamine influences the rewarding effects of nicotine in male and female adolescent Sprague-Dawley rats using conditioned place preference. Rats were pretreated with ketamine (0.0 or 20.0 mg/kg) from postnatal day (PD) 21-30 and then assessed for nicotine (0.0, 0.03, 0.1, 0.3, or 0.6 mg/kg) preference during adolescence (PD 32-42). Results indicate that female adolescent rats find nicotine to be more rewarding than male rats, however ketamine pretreatment did not affect nicotine’s effects. These findings suggest that ketamine as an antidepressant in children and adolescents may not produce adverse increases in nicotine reward.

Indexing (document details)
Advisor: Zavala, Arturo R.
Commitee: Iniguez, Sergio D., Lee, Diane W.
School: California State University, Long Beach
Department: Psychology
School Location: United States -- California
Source: MAI 55/01M(E), Masters Abstracts International
Subjects: Neurosciences, Developmental psychology
Keywords: Addiction, Ketamine, Nicotine reward
Publication Number: 1597736
ISBN: 978-1-339-01206-3
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