Organizations spend billions of dollars on information and data security, and most of this expenditure is directed externally; however, there is ample evidence in the literature that employees account for most security breaches. For information security (IS) measures to work, employees need to adopt the organization’s information system security measures. To understand employees’ adoption of security systems in the manufacturing industry in the US, this empirical study tested the extended Technology Acceptance model and Theory of Planned behavior in relation to employees’ perceptions of the IS measures usefulness, ease of use, and subjective norms and how these perceptions predicted their intention to use the security measures. Additionally, under investigation was whether age and employees’ perception of managerial support moderated the aforementioned perceptions to affect employees’ intention to use the security measures. Results of a standard multiple regression and a hierarchical regression indicated that the TAM and the TBP explained variances in the DV; however, contrary to extant literature, employees’ perceived usefulness of IS measures did not statistically significantly predict their intention to use IS measures. Implications of these findings are discussed, as well as recommendations for future research.