The purpose of this quantitative, quasi-experimental study was to measure the relationship of surgical training with simulators with the acquisition of surgical skills, and with the cost and effectiveness of surgical training program on laparoscopic colectomy. The aim was to help health care leaders identify new, effective training methods and teaching curricula. The sample of the study was eight surgeons who performed 96 laparoscopic colectomies. Participants were equally split in two groups, the experimental and the control group and had similar level of surgical experiences. Both groups attended the didactic sessions, participated in 72 assisted-surgery training cases, and completed three laparoscopic colectomies as the primary surgeons. In addition, the experimental group went through simulation training. The findings of the study indicated that simulation training had an impact on the effectiveness of laparoscopic colectomy training programs and on the cost of the laparoscopic colectomy. The patients of the experimental group had statistically significant better results in 1) the days of bowel function return, 2) the days of clearance from liquid diet, 3) the degree of post-operative pain, 4) the incidences of post-operative bleeding, 5) the days of gastric protection medication intake, and 6) the days of hospitalization compared to the patients of the control group. The results indicated that simulation training should be incorporated as a standard method of training in existing surgical curricula for laparoscopic colectomy because it could increase the adoption of laparoscopic colectomy technique, which has proven benefits against open colectomy, and could also offer qualitative results to the patients while containing health care costs.