Despite the decline in commercial development of new antibacterial agents in recent decades, bacterial antibiotic resistance continues to evolve and disseminate at an accelerating pace. Thus there is an urgent need for the development of new antibiotics to meet this growing challenge. Carbapenems, which represent the most potent members of the β-lactam class, have broad broad-spectrum activity against Gram-positive and Gram-negative pathogens. However, with the growing usage of carbapenems, resistance inevitably develops. This suggests that the development of new carbapanems, which could avoid bacterial resistance factors, would have significant clinical utility. Within this thesis I will present new antibiotics, which are designed and synthesized to potentially present more potent activity against highly resistant Gram-negative pathogens. Specifically, the new carbapenems are designed with modifications on C5 and C6 positions. Also, new synthetic methodology was developed to facilitate the use of urazoles as potential scaffolds for drug discovery.
|Commitee:||Biehl, Edward R., Son, David Y., Vik, Steven, Zoltowski, Brain|
|School:||Southern Methodist University|
|School Location:||United States -- Texas|
|Source:||DAI-B 76/09(E), Dissertation Abstracts International|
|Subjects:||Microbiology, Organic chemistry, Medicine|
|Keywords:||Antibiotics, Beta-lactams, Carbapenems, Resistances, Synthesis, Urazoles|
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