Obesity has taken a front row seat as one of the major health concerns in the United States. The literature shows that genetics, socio-economics, and advancement in technology are factors that contribute to what has become an epidemic in the country. If left treated or controlled, obesity can lead to other health problems such as diabetes and high blood pressures. Obese American adults, who have developed comorbidities, look to different therapies such as weight loss programs as a solution to improve their quality of life. The aim of the present study was to examine the effectiveness of an adult weight loss program in lowering medications and increasing physical activities. Data from a restrospective cohort of 440 adults who participated throughout eighteen sessions of a weight loss program were collected from a community hospital in Southern California. It was hypothesized that the medication intake for health problems such as diabetes and high blood pressure decrease as a result of the weight loss program. It was also hypothesized that physical activities increase as another result of the weight loss program. It was noted that the second association was supported, but not the first.