This content analysis of existing literature explored the published research supporting cognitive behavioral therapy for panic disorder and assessed if the research documented a sufficient number of Latinos in the samples of participants to be generalized for success in this population. The instruments used to measure panic disorder were assessed for cultural and linguistic validity for Latinos. The findings indicated that the research supporting CBT for panic disorder included insufficient Latino participants in the samples. Therefore, the success of CBT for Latinos with panic disorder is uncertain. Furthermore, there is paucity of culturally validated instruments that measure panic disorder. Panic disorder has been associated with many cultural expressions and syndromes that need to be adequately assessed when measuring panic disorder symptomatology.