Dissertation/Thesis Abstract

Prevalence and Correlates of Hypovitaminosis D in Children and Adolescents with Sickle Cell Disease
by McLendon, Patricia J., D.N.P., Carlow University, 2015, 79; 3701018
Abstract (Summary)

Hypovitaminosis D is associated with a variety of health conditions. Understanding the effects of low vitamin D levels on children and adolescents with sickle cell disease (SCD) remain limited. The project’s aim was to determine hypovitaminosis D prevalence in children and adolescents with SCD and explore correlates to improve current screening and treatment strategies. A retrospective, electronic health record (EHR) review was conducted on 104 children and adolescents with SCD who attended a non-profit tertiary children’s hospital in southwestern Pennsylvania. A descriptive, cross-sectional, correlational design was used to examine hypovitaminosis D prevalence and correlate vitamin D levels with comorbidities, medications, biological and environmental factors in this sample. Results demonstrated the hypovitaminosis D prevalence rate was 88.5% (< 30 ng/mL); deficiency occurred among 39% (< 20 ng/mL); subjects were 6.9 times as likely to have lower vitamin D levels in fall versus summer (p = 0.0007). Underweight subjects were 6.2 times (p = 0.0056) as likely to have lower vitamin D levels compared to healthy weight subjects. Sufficient vitamin D levels only occurred among subjects < 10. Higher probability of hypovitaminosis D was noted in subjects reporting liking milk “sometimes” versus “yes” (p = 0.0001). Hospitalizations for acute chest syndrome (ACS) had an association with vitamin D severity (p = 0.0497). The conclusion is hypovitaminosis D is prevalent among children and adolescents with SCD living in southwestern Pennsylvania. To promote future positive patient outcomes, continued identification of correlates associated with hypovitaminosis D will assist in developing well-designed prevention and treatment programs.

Indexing (document details)
Advisor: Jones, Mildred A.
Commitee: Creary, Susan, Hopkins, Clare
School: Carlow University
Department: Nursing Practice
School Location: United States -- Pennsylvania
Source: DAI-B 76/09(E), Dissertation Abstracts International
Source Type: DISSERTATION
Subjects: Nursing, Health care management
Keywords: Acute chest syndrome, Children and adolescents, Pain, Sickle cell disease, Vitamin D
Publication Number: 3701018
ISBN: 978-1-321-71347-3
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